Bipolar Today

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Two new studies in the current issue of the peer-reviewed journal Nature Genetics have found yet more genetic markers both of schizophrenia and bipolar disorder. The evidence shows eleven different genetic markers that are seen in a statistically significant way, six of which had not been seen before. Moreover, in three of these regions, there is a significant overlap where differences are seen in both schizophrenic and bipolar patients. This study is the largest of its kind, and show not only that there are standard genetic variants for people with these conditions, but that there is substantial overlap between the two conditions. Full coverage can be found at HealthCanal.

Commentary

The overlap between schizophrenia and bipolar disorder had been previously suspected, but this adds even more evidence for the connection. It is becoming clearer and clearer that the bipolar spectrum and schizophrenia are actually a part of the same spectrum. This could (and probably should) lead to a reconceptualization of the taxonomy of mental illnesses, with schizoaffective disorder being, in some ways, the “purest” manifestation of the condition. It should lead to some questions of how to define a spectrum: should it be based on symptoms or on genetics?

In addition, the more genetic markers are found for bipolar disorder, the more likely it is that a bipolar test based on genetics may be found. This may be beneficial for those who are looking for a diagnosis that is more certain. On the other hand, it risks making bipolar disorder a target for modern eugenics. Time will tell whether or not such a test will become available, and what the implications will be.

Related posts:

1. Genetic Marker for Suicidal Behavior Found
2. Similarities Found in Bipolar and Schizophrenic Brains
3. Genetic Link Discovered Between ADHD and Autism
4. “Temper Dysregulation Disorder With Dysphoria” May Replace Pediatric Bipolar Disorder
5. Filipino Café Celebrates Bipolar Disorder